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L. E. VÎJAN1,*
Fluoroquinolone carboxylic acids are antibacterial agents that attack DNA gyrase and topoisomerase IV on chromosomal DNA. In this work, the absorption spectra of ofloxacin in the presence of different amounts of calf thymus DNA are presented and discussed. The self-association of ofloxacin in aqueous solutions was considered in terms of the dimerization equilibrium and the dimerization parameters were determined. The results of the interaction between ofloxacin and DNA were rationalized in terms of the Benesi-Hildebrand, Scott, Scatchard, Wolfe and Watanabe-Schwarz models, in order to obtain the binding parameters.
Ofloxacin, Calf thymus DNA, Absorption UV-Vis spectroscopy.
L. E. VÎJAN, Absorption study of ofloxacin - DNA system, Optoelectronics and Advanced Materials - Rapid Communications, 3, 1, January 2009, pp.60-64 (2009).
Submitted at: Dec. 13, 2008
Accepted at: Jan. 21, 2009
Optoelectronics and Advanced Materials - Rapid Communications
(2023): 0.5 - 2023 Journal Citation Reports (Clarivate Analytics, 2024)
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