"

Cookies ussage consent

I agree.

Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our site without changing the browser settings you grant us permission to store that information on your device.

Feasibility study of radioluminescence film imaging: an optical way to detect medical radionuclides

LIN WANG1, XIN CAO1, XU CAO2, FEI KANG3, YONGHUA ZHAN2, XIAOWEI HE1, JING WANG3,* , XUELI CHEN2,*

Affiliation

  1. School of Information Sciences and Technology, Northwest University, Xi’an, Shaanxi 710127, China
  2. Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education & School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China
  3. Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China

Abstract

Cerenkov luminescence imaging (CLI), a promising technique to image medical radionuclides, suffers extremely low intensity level and strong attenuation of tissues, making it difficult to apply in clinic. Inspired by radioluminescence phenomenon, we propose an optical way to detect medical radionuclides, named the radioluminescence film imaging (RLFI). With the help of lab-produced film made of radioluminescence microparticles, our RLFI technology enables detection of radionuclides in a living body at a depth much deeper than current CLI method, having great potential applications in preclinical and clinical studies. We first validated the feasibility of our RLFI technology by characterizing the concentration and depth dependency of RLFI signal, and then explored its potential by in vivo imaging of radionuclide metabolism in mice..

Keywords

Cerenkov luminescence imaging, Radioluminescence film, Radioluminescence film imaging, Radioluminescence microparticles, In vivo imaging, Optical imaging, Radionuclides.

Citation

LIN WANG, XIN CAO, XU CAO, FEI KANG, YONGHUA ZHAN, XIAOWEI HE, JING WANG, XUELI CHEN, Feasibility study of radioluminescence film imaging: an optical way to detect medical radionuclides, Optoelectronics and Advanced Materials - Rapid Communications, 12, 9-10, September-October 2018, pp.542-546 (2018).

Submitted at: Dec. 25, 2017

Accepted at: Oct. 10, 2018