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In vitro assay of the antimicrobial activity of Fe3O4 and CoFe2O4 / oleic acid – core/shell on clinical isolates of bacterial and fungal strains

A. M. GRUMEZESCU1,* , D. E. MIHAIESCU1, D. E. MOGOŞANU1, M. C. CHIFIRIUC2, V. LAZAR2, I. CALUGARESCU2, V. TRAISTARU1

Affiliation

  1. Organic Chemistry Department, Faculty of Applied Chemistry and Materials Science, “Politehnica” University of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
  2. Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor 1-3, Sector 5, 60101-Bucharest, Romania

Abstract

The aim of the present study was to evaluate the antimicrobial activity of Fe3O4 and CoFe2O4 / oleic acid – core microwave conditions. The dimensions of Fe3O4 and CoFe2O4 nanoparticles did not exceed the 20 nm range and they were characterized by High Resolution Transmision Electron Microscopy. The nanoparticles were screened for their in vitro antimicrobial activity against Gram – positive (Staphylococcus aureus, Enterococcus faecalis), Gram–negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) and fungal strains (Candida albicans), using both reference and clinical, multidrug resistant strains. The quantitative assay of the antimicrobial activity was performed by both microdilution method in 96-well microplates in order to establish the minimal inhibitory concentration (MIC)..

Keywords

Antimicrobial activity, Minimum inhibitory concentration, Magnetic nanoparticles, HR-TEM.

Citation

A. M. GRUMEZESCU, D. E. MIHAIESCU, D. E. MOGOŞANU, M. C. CHIFIRIUC, V. LAZAR, I. CALUGARESCU, V. TRAISTARU, In vitro assay of the antimicrobial activity of Fe3O4 and CoFe2O4 / oleic acid – core/shell on clinical isolates of bacterial and fungal strains, Optoelectronics and Advanced Materials - Rapid Communications, 4, 11, November 2010, pp.1798-1801 (2010).

Submitted at: Oct. 27, 2010

Accepted at: Nov. 10, 2010