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Influence of physical interactions on the porosity of gelatin-alginate scaffolds

D. M. DRAGUSIN1, D. E. GIOL1, E. VASILE2, R. TRUSCA2, M. TEODORESCU1, I. STANCU1, D. S. VASILESCU1,* , H. IOVU1

Affiliation

  1. University Politehnica of Bucharest, 149 Calea Victoriei, 010072 Bucharest, Romania
  2. METAV Research & Development, C.A. Rosetti, Sector 2, Bucharest, Romania

Abstract

The present work describes the influence of physical interactions among polymer constituents on the porosity of gelatinalginate based structures. Interpenetrated polymer networks with constant gelatin loading but increasing alginate content were synthesized using a two steps cross-linking procedure. The interactions present in the biopolymers mixtures were viscometrically assessed. The morphology of the scaffolds was thereafter explained based on the dependence composition – physical forces occurring in the system before the cross-linking process. This study allows for further control of the pores size and morphology when gelatin-alginate scaffolds are needed for a specific application..

Keywords

Porous scaffold, Physical interactions, Cross-linking, Viscometry, Gelatin-alginate.

Citation

D. M. DRAGUSIN, D. E. GIOL, E. VASILE, R. TRUSCA, M. TEODORESCU, I. STANCU, D. S. VASILESCU, H. IOVU, Influence of physical interactions on the porosity of gelatin-alginate scaffolds, Optoelectronics and Advanced Materials - Rapid Communications, 5, 4, April 2011, pp.459-464 (2011).

Submitted at: March 18, 2011

Accepted at: April 11, 2011