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JOBIN JOSE1,* , R NARAYANA CHARYULU1
Clinical use of ketoconazole is limited by lipophilic nature of the drug molecule. PAMAM dendrimer provides an excellent carrier for encapsulating the drugs that has the capacity to attach and discharge drugs through various mechanisms. In this research work, the solubilization mechanism, in vitro release studies of ketoconazole- PAMAM complex were investigated. The experimental results suggested that an increase in dendrimer concentration and generation results in an increase in aqueous solubility of ketoconazole. In vitro release study revealed the sustained release of the drug from drug dendrimer complex..
PAMAM Dendrimer, Ketoconazole, Solubilization.
JOBIN JOSE, R NARAYANA CHARYULU, PAMAM Dendrimers: novel polymeric nanoarchitectures for solubility enhancement of Ketoconazole, Optoelectronics and Advanced Materials - Rapid Communications, 10, 7-8, July-August 2016, pp.604-608 (2016).
Submitted at: Sept. 24, 2015
Accepted at: Aug. 3, 2016
Optoelectronics and Advanced Materials - Rapid Communications
(2022): 0.5 - 2022 Journal Citation Reports (Clarivate Analytics, 2023)
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