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Protein adsorption and oxidative properties of some cellulose-modified polyurethane membranes for medical applications

M. BUTNARU1,2,* , D. MACOCINSCHI1, C. D. DIMITRIU3, S. VLAD1, D. FILIP1, V. HARABAGIU1

Affiliation

  1. “Petru Poni” Institute of Macromolecular Chemistry, 41A, Aleea Grigore Ghica Voda, 700487 Iasi, Romania
  2. Department of Medical Bioengineering, “Grigore T. Popa” University of Medicine and Pharmacy, 9-13, Kogalniceanu str, 700454 Iasi, Romania
  3. Department of Biochemistry, ”Grigore T. Popa” University of Medicine and Pharmacy, 16, Universitatii str, 700115 Iasi, Romania

Abstract

Polyurethane (PU) materials are easily adaptable materials to many medical applications if biocompatibility characteristics can be assured. To improve the biocompatibility, PU samples obtained from poly(ethylene adipate)diol (PEGA), polytetrahydrofuran (PTHF) or poly(propylene)glycol (PPG) as soft segments and 4',4’-diphenylmethanediisocyanate were blended with hydroxypropylcellulose (HPC). The investigation of the functional integration capacity of the newly prepared materials was performed. All materials have slightly positive surface charge, the samples showed preferential adsorption of serum albumin (SA). PUPTHF/HPC with ζ potential close to neutral, lowest FB adsorption properties and higher SA/FB adsorbed ratio was found to be the most bio-adaptable sample..

Keywords

Polyurethane/hydroxypropylcellulose blends, Protein adsorption, Oxidative properties.

Citation

M. BUTNARU, D. MACOCINSCHI, C. D. DIMITRIU, S. VLAD, D. FILIP, V. HARABAGIU, Protein adsorption and oxidative properties of some cellulose-modified polyurethane membranes for medical applications, Optoelectronics and Advanced Materials - Rapid Communications, 5, 2, February 2011, pp.172-176 (2011).

Submitted at: Dec. 27, 2010

Accepted at: Feb. 17, 2011