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Sensitive device for ions of biological interest

E. EFTIMIE TOTU1,* , E. RUSE1, I. GHICA1, D. MANUC2

Affiliation

  1. Department of Analytical and Instrumental Analysis, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Str. Polizu 1 -4, Bucharest, Romania
  2. Department of Public Health, University of Medicine and Pharmacy Carol Davila, Eforie Str., no.4, 5 Bucharest, Romania

Abstract

The objective of this paper was to study the suitability of ion sensitive field effect transistors (ISFETs) for clinical work with special reference to a flow cell assembly. This was intended for use in the analysis of biological fluids, where the concentrations of specific ions, e.g. calcium, potassium, are closely monitored. Evaluations the new electrochemical assembly, for use in clinical chemistry, were made. Also, ETH 2041 (tetra - n – undecil 3, 3’ ,4, 4’ – benzophenone tetracarboxylate) and DOS ( bis ( 2 –ethylhexyl) sebacate) plasticizers were used and their performances compared, proving that the proposed plasticizer ETH 2041 improves the electrochemical characteristics of the selective device finally obtained. Several points have arisen in this investigation with regard to the flow cell requirements and these are discussed as appropriate.

Keywords

Dialysis flow-cell, ISFET, Ion selective membrane, Biological fluids.

Citation

E. EFTIMIE TOTU, E. RUSE, I. GHICA, D. MANUC, Sensitive device for ions of biological interest, Optoelectronics and Advanced Materials - Rapid Communications, 2, 8, August 2008, pp.502-506 (2008).

Submitted at: June 25, 2008

Accepted at: July 16, 2008