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Simultaneous multimodality molecular imaging with neodymium-doped Y3Al5O12 nanoparticles

YONGHUA ZHAN1, XU CAO1, XIN CAO1, FEI KANG2, JING WANG2, JIMIN LINAG1, ZHIMIN LI3,* , XUELI CHEN1,*

Affiliation

  1. Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education & School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China
  2. Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
  3. School of Advanced Materials and Nanotechnology, Xidian University, Xi’an, Shaanxi710071, China

Abstract

Capturing simultaneously multimodality information using one imaging agent is a new direction of molecular imaging technology. In this work, we report a proof-of-concept study that uses trimodality imaging consisting of fluorescence imaging (FI), X-ray excited luminescence imaging (XEL), and radionuclide excited luminescence imaging (REL), with the injection of only one kind of Nd3+:Y3Al5O12 nanoparticles. The spectrum measurements and the results of in vivo pseudo-tumor based experiments validated the capability of Nd3+:Y3Al5O12 nanoparticles as agents for trimodality imaging. This proof-of-concept study may open the door for the rapid development of multimodality imaging technology that facilitates the acquisition of a large novel information to be simultaneously obtained using one imaging agent and one imaging system..

Keywords

Multimodality imaging, Simultaneous imaging, Nd3+:Y3Al5O12 nanoparticles.

Citation

YONGHUA ZHAN, XU CAO, XIN CAO, FEI KANG, JING WANG, JIMIN LINAG, ZHIMIN LI, XUELI CHEN, Simultaneous multimodality molecular imaging with neodymium-doped Y3Al5O12 nanoparticles, Optoelectronics and Advanced Materials - Rapid Communications, 10, 9-10, September-October 2016, pp.685-688 (2016).

Submitted at: Oct. 22, 2015

Accepted at: Sept. 29, 2016