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M. C. SHARMA1,* , S. SHARMA2, S. C. CHATURVEDI1
A specific, sensitive, precise and reproducible spectrophotometric method has been developed for the simultaneous estimation of Atorvastatin Calcium and Pioglitazone in tablet dosage form. An ultraviolet (UV) spectrophotometic method was developed and validated for quantitative determination of Atorvastatin Calcium and Pioglitazone in combined dosage form using methanol as solvent. The proposed method is based on simultaneous equation method. The absorption maxima (λmax) of Atorvastatin and Pioglitzone were 245 and 226nm respectively. The calibration curves were prepared. The proposed method obeys Beers law in concentration range 5-35 μg/ml for Atorvastatin Calcium and Pioglitazone respectively with correlation coefficients were found to be 0.9960 and 0.9967 respectively. The method was contempt using known concentration of drug and percentage recovery was found in the range of 99 % to 101 %. Analyzing the combination in tablet dosage form, recovery study showed a good agreement in the assay of results. The proposed method is simple, precise and accurate and can be employed for routine analysis of Atorvastatin Calcium and pioglitazone in tablet dosage form..
Atorvastatin calcium, Pioglitazone, Simultaneous equation, Derivative spectrophotometry method, Area under curve.
M. C. SHARMA, S. SHARMA, S. C. CHATURVEDI, Simultaneous spectroscopic estimation and validation of atorvastatin calcium and pioglitazone in a tablet dosage form, Optoelectronics and Advanced Materials - Rapid Communications, 4, 3, March 2010, pp.422-426 (2010).
Submitted at: Nov. 24, 2009
Accepted at: March 12, 2010
Optoelectronics and Advanced Materials - Rapid Communications
(2023): 0.5 - 2023 Journal Citation Reports (Clarivate Analytics, 2024)
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