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Size separation of ultrafine PEG-coated polycaprolactone nanoparticle and morphological studies by AFM

CHIH-HANG CHU1, YU-CHAO WANG2, LI-CHEN WU1, CHUNG-SHI YANG1,2,*

Affiliation

  1. Department of Applied Chemistry and Graduate Institute of Biomedicine and Biomedical Technology, National Chi-Nan University, Puli, Taiwan
  2. Center for Nanomedicine Research, National Health Research Institutes, 35 Keyand Rd. Zhunan, Mialoli 350, Taiwan, R. O. C.

Abstract

Novel ultrafine polycaprolactone nanoparticles (PCL NPs) were prepared using poly(ethyleneglycol)2000-distearyl phosphoethanolamine (PEGPE) as the oily phase emulsifier in the emulsion process, resulting in PEG-coated PCL NPs (PEGPE-PCL), which could be reduced and confined in size to below 50 nm. Size separation of PEG-coated polymer NPs remain significant challenges in the preparation for fundamental studies and applications. We used a gel filtration chromatography method for the rapid size separation of PEGPE-PCL and studied the physicochemical characteristics. The morphology of the core-shell PEGPE-PCL on a mica surface followed by NP concentration was observed by atomic force microscopy (AFM). It is important to separate size and define PEGPE-PCL structure for further potential in drug delivery application..

Keywords

Polymeric composites, Nanoparticles, Atomic force microscopy, Biomaterial.

Citation

CHIH-HANG CHU, YU-CHAO WANG, LI-CHEN WU, CHUNG-SHI YANG, Size separation of ultrafine PEG-coated polycaprolactone nanoparticle and morphological studies by AFM, Optoelectronics and Advanced Materials - Rapid Communications, 5, 9, September 2011, pp.969-972 (2011).

Submitted at: Aug. 8, 2011

Accepted at: Sept. 15, 2011