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Soft chemical methods integration with micro fabrication in developing new scaffolds for tissue engineering

R. M. PITICESCU1,* , T. BURUIANA2, N. PLESU3, E. VASILE4, C. MOLDOVAN5, B. FARTAT5, C. RUSTI1

Affiliation

  1. R&D Institute for Non-Ferrous and Rare Metals., Pantelimon-Ilfov, Romania
  2. Institute for Macromolecular Chemistry “Petru Poni”, Iassy, Romania
  3. Institute for Chemistry of the Romanian Academy, Timisoara, Romania
  4. S.C.METAV R&D S.A., Bucharest, Romania
  5. National R&D Institute for Microtechnologies, Bucharest, Romania

Abstract

The aim of the work is to develop new scaffolds for tissue engineering. This supposes to integrate soft chemical methods (hydrothermal and electrochemical methods) for preparing multifunctional biomaterials based on hydroxyl apatite and functionalized polyurethanes. The innovative part is represented by the following aspects: in situ synthesis under hydrothermal conditions at low temperatures and high pressures of new nanostructured hybrid materials with a strong chemical/physical bonding between the components; applying the cyclic voltametry to monitor the electrical response of the nanostructured hybrid thin films deposited by spin-coating on gold-plated silicon wafers used as substrate. To accomplish these studies, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed. Depending on the structural and compositional factors of the nanostructured hybrid thin films, the electrical response could be useful in monitoring by electrical stimulation of the cell response. SEM and HRTEM methods have been used to characterize the morphology of nanostructured hybrid powders. Biocompatibility studies by in-vitro tests of different immobilized biomolecules are under working..

Keywords

Nanostructured hybrid organic-inorganic materials, Electrochemical methods, Tissue engineering.

Citation

R. M. PITICESCU, T. BURUIANA, N. PLESU, E. VASILE, C. MOLDOVAN, B. FARTAT, C. RUSTI, Soft chemical methods integration with micro fabrication in developing new scaffolds for tissue engineering, Optoelectronics and Advanced Materials - Rapid Communications, 4, 3, March 2010, pp.401-406 (2010).

Submitted at: Dec. 18, 2010

Accepted at: March 12, 2010