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L. E. VÎJAN1,* , I. PUICĂ1
The spectroscopic behavior of enoxacin has been investigated in aqueous solutions. The absorption spectra of enoxacin - DNA system were measured and interpreted. The binding of enoxacin to calf thymus DNA was considered in terms of Benesi-Hildebrand, Scott, Scatchard and Wolfe methods. The number of absorbing species presents in solution, the binding constant and the number of binding sites for each segment of DNA were determined. The modifications observed in the absorption spectra were interpreted in terms of the stacking of drug molecules, fixed by electrostatic interactions to the anionic groups from the biopolymer..
Enoxacin, Fluoroquinolones, Calf thymus DNA, UV-Vis absorption spectroscopy.
L. E. VÎJAN, I. PUICĂ, Spectral study of the interaction between enoxacin and calf thymus DNA, Optoelectronics and Advanced Materials - Rapid Communications, 4, 12, December 2010, pp.2129-2131 (2010).
Submitted at: Nov. 13, 2010
Accepted at: Nov. 29, 2010
Optoelectronics and Advanced Materials - Rapid Communications
(2023): 0.5 - 2023 Journal Citation Reports (Clarivate Analytics, 2024)
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