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V. NASTASA1,* , V. PRADINES2, I. R. ANDREI1, M. BONI1, M. L. PASCU1, R. MILLER2
The development of bacteria resistance to antibiotic treatment is considered a natural evolution process. A consequence of this resistance is the decrease of the effectiveness of the antibiotics that causes a lower quality of life and the morbidity increase in patients. The same is true for malignant tumors. Since the development of new drugs does not keep the pace with the developed resistance, there is an immediate need to identify new strategies for the improvement of the existing antibiotics efficacy. The reversal of the antibiotics resistance includes not only the treatment against pathogens which directly affect the patient’s health but also the fight against the microbes developed in the hospital environment due to repetitive disinfection. The resistance to antibiotic treatment is also signalled as multidrug resistance (MDR) at simultaneous treatment with different drugs. One way to fight MDR can be represented by the use of new vectors to transport the medicines to their targets such as simple droplets of medicines solutions and layered droplets consisting of the active medicine core (Vancomycin in our case), covered by a layer of a oily substance (vitamin A in sunflower oil in this report)..
Micro-droplets, Nano-droplets, Surface tension, Contact angle, Multidrug resistance.
V. NASTASA, V. PRADINES, I. R. ANDREI, M. BONI, M. L. PASCU, R. MILLER, Studies about the generation and characterisation of microdroplets with a controlled content, Optoelectronics and Advanced Materials - Rapid Communications, 4, 11, November 2010, pp.1916-1919 (2010).
Submitted at: Oct. 1, 2010
Accepted at: Nov. 10, 2010
Optoelectronics and Advanced Materials - Rapid Communications
(2023): 0.5 - 2023 Journal Citation Reports (Clarivate Analytics, 2024)
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