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Synchronous autofluorescence spectroscopy of gastrointestinal tumours tool for endogenous fluorophores evaluation

E. BORISOVA1,* , TS. GENOVA1, AL. ZHELYAZKOVA1, L. ANGELOVA1, M. KEREMEDCHIEV2, N. PENKOV2, I. TERZIEV2, B. VLADIMIROV2, O. SEMYACHKINA-GLUSHKOVSKAYA3, L. AVRAMOV1

Affiliation

  1. Institute of Electronics, Bulgarian Academy of Sciences, 72, Tsarigradsko Chaussee Blvd., 1784, Sofia, Bulgaria
  2. University hospital “Tsaritsa Yoanna- ISUL”, 8, “Byalo more” str., 1527 Sofia, Bulgaria
  3. Biology Department, Saratov State University, Physiology of Human and Animals lab., 83 Astrakhanskaya str., Saratov, Russia

Abstract

Synchronous autofluorescence spectroscopy (SFS) using excitation in the range of 280-440 nm and varying delta lambda from 10 to 200 nm were applied on lower GIT tumours obtained after surgical excision. Due to the improved efficiency of SFS for the signals, where the delta lambda is optimal, we could obtain higher spectral resolution for the detection of the set of endogenous fluorophores. Major spectral features are addressed and diagnostic discrimination algorithms based on lesions’ emission properties are proposed..

Keywords

Synchronous fluorescence spectroscopy, Excitation-emission matrix, Gastrointestinal tumour, Colon carcinoma.

Citation

E. BORISOVA, TS. GENOVA, AL. ZHELYAZKOVA, L. ANGELOVA, M. KEREMEDCHIEV, N. PENKOV, I. TERZIEV, B. VLADIMIROV, O. SEMYACHKINA-GLUSHKOVSKAYA, L. AVRAMOV, Synchronous autofluorescence spectroscopy of gastrointestinal tumours tool for endogenous fluorophores evaluation, Optoelectronics and Advanced Materials - Rapid Communications, 9, 9-10, September-October 2015, pp.1234-1238 (2015).

Submitted at: July 1, 2015

Accepted at: Sept. 9, 2015